Huang Lab

Publications

Publications

Browse recent publications with filters for title, author, journal, and year.

Last updated

July 20, 2026

Showing 1–25 of 143 publications · Page 1 of 6

2026

CAR T Cell Therapy in Solid Tumors: Lessons From Early-Phase Clinical Trials and Biological Barriers to Efficacy

Liu K, Pham VT, Fu S, Sun L, Huang G

Hematological oncology · 2026 Jul · PMID 42294616

View on PubMed DOI: 10.1002/hon.70209

2026

Valosin-Containing Protein Contributes to Plexiform Neurofibroma Formation and Represents a Novel Therapeutic Target

Gopalan L, Na Y, Hu L, Hall A, Kim MO, Dombi E, Szabo S, Ratner N, Huang G, Wu J

Cells · 2026 May 6 · PMID 42121950

View on PubMed DOI: 10.3390/cells15090848

2026

Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic state

Bai J, Araki K, Kurotaki D, Eerdunduleng, Sorin S, Hiramatsu K, Uno N, Hamashima A, Iimori M, Kikuchi K, Terashima M, Kubota S, Kohrogi K, Huang G, Ogawa M, Oshimura M, Kazuki Y, Sashida G

Oncogene · 2026 May · PMID 41933136

View on PubMed DOI: 10.1038/s41388-026-03763-3

2026

Insights and modulation of RNA polymerase-dependent R-loop and dsRNA in Fanconi anemia hematopoietic stem cells

Hashimoto M, Feng X, Bai J, Zeng H, Li T, Li J, Umemoto T, Andreassen PR, Huang G

JCI insight · 2026 Apr 8 · PMID 41746738

View on PubMed DOI: 10.1172/jci.insight.192126

2026

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease

Sezaki M, Li T, Pan M, Wang Z, Bai J, Horowitz JG, Xu JZ, Huang G

The Journal of clinical investigation · 2026 Feb 2 · PMID 41623180

View on PubMed DOI: 10.1172/JCI197706

2025

The RNA N(6)-methyladenosine methylome coordinates long non-coding RNAs to mediate cancer drug resistance by activating PI3K signaling

Tan Y, Zhou C, Bian S, Bian H, Ren Y, Walter W, Pang J, Cheng T, Wang H, Yang Y, Guo W, Zhang L, Al-Kali A, Litzow MR, Han X, Yu J, Yang R, Huang G, Hoermann G, Tse W, Liu S

Cell death & disease · 2025 Nov 7 · PMID 41203598

View on PubMed DOI: 10.1038/s41419-025-08045-6

2025

Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1(S34F) mutant myelodysplastic neoplasms

Zhang W, Li B, Liu J, Yan Y, Yang L, Qin T, Xu Z, Sun Q, Jia Y, Wang H, Huang G, Wang H, Shi L, Zhou J, Xiao Z

Leukemia · 2025 Sep · PMID 40652060

View on PubMed DOI: 10.1038/s41375-025-02684-6

2025

Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells

Shi Z, Zhang X, Yang H, Zheng X, Niu M, Zhang Y, Yuan P, Wei W, Huang G, Fang R, Chen L

Blood science (Baltimore, Md.) · 2025 Jun · PMID 40416726

View on PubMed DOI: 10.1097/BS9.0000000000000236

2025

Integrated Computational and Functional Screening Identifies G9a Inhibitors for SETD2-mutant Leukemia

Zhang Y (张亚), Xia M (夏梦芳), Yi Z (易真伊), Sui P (岁品品), He X (何旭东), Wang L (王丽萍), Chen Q (陈祺仪), Zhu HH (主鸿鹄), Huang G (黄刚), Wang QF (王前飞)

Genomics, proteomics & bioinformatics · 2025 May 30 · PMID 40300107

View on PubMed DOI: 10.1093/gpbjnl/qzaf035

2025

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory

Timilsina S, Huang JY, Abdelfattah N, Medina D, Singh D, Abdulsahib S, Subbarayalu P, Do TP, Venkata PP, Nirzhor S, Prochnau J, Bhandari M, Zheng S, Chen Y, Huang G, Mukherjee N, Hromas R, Sung P, Kaklamani V, Vadlamudi R, Zhang N, Rao MK

Nature communications · 2025 Apr 28 · PMID 40295473

View on PubMed DOI: 10.1038/s41467-025-59186-3

2025

Age-Dependent Bi-Phasic Dynamics of Ly49(+)CD8(+) Regulatory T Cell Population

Srinivasan S, Mishra S, Fan KK, Wang L, Im J, Segura C, Mukherjee N, Huang G, Rao M, Ma C, Zhang N

Aging cell · 2025 Apr · PMID 39696807

View on PubMed DOI: 10.1111/acel.14461

2025

CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor Therapy

Bian H, Zhou C, Koyama H, Gao W, Bian S, Cheng T, Han X, Tse W, Miron A, Liu S

RNA nanomed · 2025 Apr · PMID 42004278

View on PubMed DOI: 10.59566/isrnn.2025.0201e

2025

Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling

Cui X, Hou L, Yan B, Liu J, Zhang C, Sui P, Tong S, Luchsinger L, Mendelson A, Zhou D, Yang FC, Zhong H, Liang Y

The Journal of clinical investigation · 2025 Jan 21 · PMID 39836478

View on PubMed DOI: 10.1172/JCI182125

2025

Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells

Li J, Bai J, Pham VT, Hashimoto M, Sezaki M, Shi Q, Jin Q, He C, Armstrong A, Li T, Pan M, Liu S, Luan Y, Zeng H, Andreassen PR, Huang G

The Journal of clinical investigation · 2025 Jan 9 · PMID 39786963

View on PubMed DOI: 10.1172/JCI184069

2024

The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances

Yao P, Liu YG, Huang G, Hao L, Wang R

Experimental hematology & oncology · 2024 Dec 4 · PMID 39633491

View on PubMed DOI: 10.1186/s40164-024-00583-7

2024

The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer

Hassouneh Z, Kim ME, Bowman N, Rao M, Zhang N, Huang G, Svatek RS, Mukherjee N

Cancers · 2024 Sep 27 · PMID 39409924

View on PubMed DOI: 10.3390/cancers16193303

2024

Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease

Ge G, Sivasubramanian BP, Geng BD, Zhao S, Zhou Q, Huang G, O'Connor JC, Clark RA, Li S

Gene therapy · 2024 May · PMID 38627469

View on PubMed DOI: 10.1038/s41434-024-00451-3

2024

Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Luo Y, Feng X, Lang W, Xu W, Wang W, Mei C, Ye L, Zhu S, Wang L, Zhou X, Zeng H, Ma L, Ren Y, Jin J, Xu R, Huang G, Tong H

The Journal of clinical investigation · 2024 Feb 22 · PMID 38386414

View on PubMed DOI: 10.1172/JCI172468

2023

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G

The Journal of experimental medicine · 2023 Jul 3 · PMID 37071125

View on PubMed DOI: 10.1084/jem.20220962

2023

A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation

Wang C, Tu Z, Cai X, Wang W, Davis AK, Nattamai K, Paranjpe A, Dexheimer P, Wu J, Huang FL, Geiger H, Huang G, Zheng Y

Blood advances · 2023 Jun 13 · PMID 36661340

View on PubMed DOI: 10.1182/bloodadvances.2022008591