2026 Jun
mRNA vaccination targeting AML1::ETO fusion gene eliminates leukemia cells via activating T cells
Zhou C, Bian S, Pang J, Bian H, Cheng T, Koyama H, Liu B, Li B, Tse W, Liu S
Leukemia · DOI 10.1038/s41375-026-02940-3 · PMID 41963593
Publications
Publications
Browse recent publications with filters for title, author, journal, and year.
2026 May
Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic state
Bai J, Araki K, Kurotaki D, Eerdunduleng, Sorin S, Hiramatsu K, Uno N, Hamashima A, Iimori M, Kikuchi K, Terashima M, Kubota S, Kohrogi K, Huang G, Ogawa M, Oshimura M, Kazuki Y, Sashida G
Oncogene · DOI 10.1038/s41388-026-03763-3 · PMID 41933136
2026 Apr 8
Insights and modulation of RNA polymerase-dependent R-loop and dsRNA in Fanconi anemia hematopoietic stem cells
Hashimoto M, Feng X, Bai J, Zeng H, Li T, Li J, Umemoto T, Andreassen PR, Huang G
JCI insight · DOI 10.1172/jci.insight.192126 · PMID 41746738
2026 Mar
Driver mutation-defined molecular landscapes of essential thrombocythemia
Lorenzen AL, Huang G
Blood science (Baltimore, Md.) · DOI 10.1097/BS9.0000000000000273 · PMID 41552765
2026 March
Valosin-Containing Protein Contributes to Plexiform Neurofibroma Formation and Represents a Novel Therapeutic Target
Gopalan L, Na Y, Hu L, Hall A, Kim M, Dombi E, Szabo S, Ratner N, Huang G, Wu J.
Cells · DOI 10.3390/cells15090848
2026 Feb 2
Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease
Sezaki M, Li T, Pan M, Wang Z, Bai J, Horowitz JG, Xu JZ, Huang G
The Journal of clinical investigation · DOI 10.1172/JCI197706 · PMID 41623180
2025 Nov 7
The RNA N(6)-methyladenosine methylome coordinates long non-coding RNAs to mediate cancer drug resistance by activating PI3K signaling
Tan Y, Zhou C, Bian S, Bian H, Ren Y, Walter W, Pang J, Cheng T, Wang H, Yang Y, Guo W, Zhang L, Al-Kali A, Litzow MR, Han X, Yu J, Yang R, Huang G, Hoermann G, Tse W, Liu S
Cell death & disease · DOI 10.1038/s41419-025-08045-6 · PMID 41203598
2025 Sep
Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1(S34F) mutant myelodysplastic neoplasms
Zhang W, Li B, Liu J, Yan Y, Yang L, Qin T, Xu Z, Sun Q, Jia Y, Wang H, Huang G, Wang H, Shi L, Zhou J, Xiao Z
Leukemia · DOI 10.1038/s41375-025-02684-6 · PMID 40652060
2025 Aug 1
Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies
Huang J, Pham VT, Fu S, Huang G, Liu YG, Zheng L
Journal of hematology & oncology · DOI 10.1186/s13045-025-01727-w · PMID 40750884
2025 Jun
Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells
Shi Z, Zhang X, Yang H, Zheng X, Niu M, Zhang Y, Yuan P, Wei W, Huang G, Fang R, Chen L
Blood science (Baltimore, Md.) · DOI 10.1097/BS9.0000000000000236 · PMID 40416726
2025 May 30
Integrated Computational and Functional Screening Identifies G9a Inhibitors for SETD2-mutant Leukemia
Zhang Y (张亚), Xia M (夏梦芳), Yi Z (易真伊), Sui P (岁品品), He X (何旭东), Wang L (王丽萍), Chen Q (陈祺仪), Zhu HH (主鸿鹄), Huang G (黄刚), Wang QF (王前飞)
Genomics, proteomics & bioinformatics · DOI 10.1093/gpbjnl/qzaf035 · PMID 40300107
2025 Apr 28
Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory
Timilsina S, Huang JY, Abdelfattah N, Medina D, Singh D, Abdulsahib S, Subbarayalu P, Do TP, Venkata PP, Nirzhor S, Prochnau J, Bhandari M, Zheng S, Chen Y, Huang G, Mukherjee N, Hromas R, Sung P, Kaklamani V, Vadlamudi R, Zhang N, Rao MK
Nature communications · DOI 10.1038/s41467-025-59186-3 · PMID 40295473
2025 Apr
Age-Dependent Bi-Phasic Dynamics of Ly49(+)CD8(+) Regulatory T Cell Population
Srinivasan S, Mishra S, Fan KK, Wang L, Im J, Segura C, Mukherjee N, Huang G, Rao M, Ma C, Zhang N
Aging cell · DOI 10.1111/acel.14461 · PMID 39696807
2025 Apr
CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor Therapy
Bian H, Zhou C, Koyama H, Gao W, Bian S, Cheng T, Han X, Tse W, Miron A, Liu S
RNA nanomed · DOI 10.59566/isrnn.2025.0201e · PMID 42004278
2025 Jan 21
Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling
Cui X, Hou L, Yan B, Liu J, Zhang C, Sui P, Tong S, Luchsinger L, Mendelson A, Zhou D, Yang FC, Zhong H, Liang Y
The Journal of clinical investigation · DOI 10.1172/JCI182125 · PMID 39836478
2025 Jan 9
Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells
Li J, Bai J, Pham VT, Hashimoto M, Sezaki M, Shi Q, Jin Q, He C, Armstrong A, Li T, Pan M, Liu S, Luan Y, Zeng H, Andreassen PR, Huang G
The Journal of clinical investigation · DOI 10.1172/JCI184069 · PMID 39786963
2024 Dec 4
The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances
Yao P, Liu YG, Huang G, Hao L, Wang R
Experimental hematology & oncology · DOI 10.1186/s40164-024-00583-7 · PMID 39633491
2024 Sep 27
The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer
Hassouneh Z, Kim ME, Bowman N, Rao M, Zhang N, Huang G, Svatek RS, Mukherjee N
Cancers · DOI 10.3390/cancers16193303 · PMID 39409924
2024 May
Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease
Ge G, Sivasubramanian BP, Geng BD, Zhao S, Zhou Q, Huang G, O'Connor JC, Clark RA, Li S
Gene therapy · DOI 10.1038/s41434-024-00451-3 · PMID 38627469
2024 Feb 22
Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes
Luo Y, Feng X, Lang W, Xu W, Wang W, Mei C, Ye L, Zhu S, Wang L, Zhou X, Zeng H, Ma L, Ren Y, Jin J, Xu R, Huang G, Tong H
The Journal of clinical investigation · DOI 10.1172/JCI172468 · PMID 38386414
2024
Into the storm: the imbalance in the yin-yang immune response as the commonality of cytokine storm syndromes
Armstrong A, Tang Y, Mukherjee N, Zhang N, Huang G
Frontiers in immunology · DOI 10.3389/fimmu.2024.1448201 · PMID 39318634
2023 Aug 10
Food for thought (and CML survival)
Sezaki M, Huang G
Blood · DOI 10.1182/blood.2023021051 · PMID 37561542
2023 Jul 3
Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs
Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G
The Journal of experimental medicine · DOI 10.1084/jem.20220962 · PMID 37071125
2023 Jun 13
A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation
Wang C, Tu Z, Cai X, Wang W, Davis AK, Nattamai K, Paranjpe A, Dexheimer P, Wu J, Huang FL, Geiger H, Huang G, Zheng Y
Blood advances · DOI 10.1182/bloodadvances.2022008591 · PMID 36661340
2023 Mar
Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis
Na Y, Hall A, Yu Y, Hu L, Choi K, Burgard JA, Szabo S, Huang G, Ratner N, Wu J
Oncogene · DOI 10.1038/s41388-023-02620-x · PMID 36759572