Huang Lab

Publications

Publications

Browse recent publications with filters for title, author, journal, and year.

Last updated

July 20, 2026

Showing 101–125 of 143 publications · Page 5 of 6

2015

A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes

Feng G, Gale RP, Cui W, Cai W, Huang G, Xu Z, Qin T, Zhang Y, Li B, Fang L, Zhang H, Pan L, Hu N, Qu S, Wang J, Cui Y, Xiao Z

Experimental hematology & oncology · 2015 · PMID 27127725

View on PubMed DOI: 10.1186/s40164-016-0041-6

2015

Impact of TET2, SRSF2, ASXL1 and SETBP1 mutations on survival of patients with chronic myelomonocytic leukemia

Cui Y, Tong H, Du X, Li B, Gale RP, Qin T, Liu J, Xu Z, Zhang Y, Huang G, Jin J, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

Experimental hematology & oncology · 2015 · PMID 26019984

View on PubMed DOI: 10.1186/s40164-015-0009-y

2014

Cytogenetic studies and their prognostic contribution in 565 Chinese patients with primary myelofibrosis

Li B, Xu J, Li C, Gale RP, Xu Z, Qin T, Zhang Y, Huang G, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

American journal of hematology · 2014 Nov · PMID 25132428

View on PubMed DOI: 10.1002/ajh.23824

2014

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells

Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG

Blood · 2014 Oct 9 · PMID 25185713

View on PubMed DOI: 10.1182/blood-2014-01-550855

2014

PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway

Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, Guan Y, Zhao X, Yan J, Ni J, Nobrega MA, Löwenberg B, Delwel R, Valk PJ, Kumar A, Xie L, Tenen DG, Huang G, Wang QF

Leukemia · 2014 Jul · PMID 24445817

View on PubMed DOI: 10.1038/leu.2013.384

2014

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A

Nature communications · 2014 Jun 23 · PMID 24953053

View on PubMed DOI: 10.1038/ncomms5177

2014

Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions

Cui R, Gale RP, Zhu G, Xu Z, Qin T, Zhang Y, Huang G, Li B, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

Leukemia research · 2014 May · PMID 24598841

View on PubMed DOI: 10.1016/j.leukres.2014.01.016

2014

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G

Blood · 2014 Mar 13 · PMID 24449215

View on PubMed DOI: 10.1182/blood-2013-03-489575

2014

Identification of functional cooperative mutations of SETD2 in human acute leukemia

Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G, Cheng T, Wang QF

Nature genetics · 2014 Mar · PMID 24509477

View on PubMed DOI: 10.1038/ng.2894

2013

A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis

Li A, Yang Y, Gao C, Lu J, Jeong HW, Liu BH, Tang P, Yao X, Neuberg D, Huang G, Tenen DG, Chai L

The Journal of clinical investigation · 2013 Oct · PMID 24051379

View on PubMed DOI: 10.1172/JCI62891

2013

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, Mulloy JC

The Journal of clinical investigation · 2013 Sep · PMID 23979164

View on PubMed DOI: 10.1172/JCI68557

2013

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment

Schönheit J, Kuhl C, Gebhardt ML, Klett FF, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA, Rosenbauer F

Cell reports · 2013 May 30 · PMID 23623495

View on PubMed DOI: 10.1016/j.celrep.2013.04.007

2013

Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line

Zhao X, Zhao Z, Guo J, Huang P, Zhu X, Zhou X, Yang Z, Zhao L, Xu L, Xu J, Fu L, Zhang J, Zhang X, Dong Y, Huang G, Wang Q, Li B, Song X, Yang X, Liu S, Yi S, Yu T, Yu C, Hou L, Li J, Chen W

Journal of biomolecular screening · 2013 Apr · PMID 23042077

View on PubMed DOI: 10.1177/1087057112463066

2013

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG

Molecular cell · 2013 Mar 7 · PMID 23395001

View on PubMed DOI: 10.1016/j.molcel.2013.01.007

2013

Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β

Hirai H, Kamio N, Huang G, Matsusue A, Ogino S, Kimura N, Satake S, Ashihara E, Imanishi J, Tenen DG, Maekawa T

PloS one · 2013 · PMID 23382991

View on PubMed DOI: 10.1371/journal.pone.0054862

2012

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Zorko NA, Bernot KM, Whitman SP, Siebenaler RF, Ahmed EH, Marcucci GG, Yanes DA, McConnell KK, Mao C, Kalu C, Zhang X, Jarjoura D, Dorrance AM, Heerema NA, Lee BH, Huang G, Marcucci G, Caligiuri MA

Blood · 2012 Aug 2 · PMID 22674806

View on PubMed DOI: 10.1182/blood-2012-03-415067

2012

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

Zhang Y, Yan X, Sashida G, Zhao X, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot K, Conway RM, Witte D, Wang QF, Tenen DG, Xiao Z, Marcucci G, Mulloy JC, Grimes HL, Caligiuri MA, Huang G

Blood · 2012 Aug 2 · PMID 22740449

View on PubMed DOI: 10.1182/blood-2012-02-412379

2011

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD

Blood · 2011 Dec 15 · PMID 22012064

View on PubMed DOI: 10.1182/blood-2010-11-317909

2011

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG

The EMBO journal · 2011 Aug 26 · PMID 21873977

View on PubMed DOI: 10.1038/emboj.2011.285

2011

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD

Science (New York, N.Y.) · 2011 Aug 5 · PMID 21764752

View on PubMed DOI: 10.1126/science.1201662

2011

MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML

Xiong Y, Li Z, Ji M, Tan AC, Bemis J, Tse JV, Huang G, Park J, Ji C, Chen J, Bemis LT, Bunting KD, Tse W

British journal of haematology · 2011 Jun · PMID 21496004

View on PubMed DOI: 10.1111/j.1365-2141.2011.08662.x