Huang Lab

Publications

Publications

Browse recent publications with filters for title, author, journal, and year.

Last updated

July 20, 2026

Showing 26–50 of 143 publications · Page 2 of 6

2022

Excessive IL-10 and IL-18 trigger hemophagocytic lymphohistiocytosis-like hyperinflammation and enhanced myelopoiesis

Tang Y, Xu Q, Luo H, Yan X, Wang G, Hu L, Jin J, Witte DP, Marsh RA, Huang L, Huang G, Zhou J

The Journal of allergy and clinical immunology · 2022 Nov · PMID 35792218

View on PubMed DOI: 10.1016/j.jaci.2022.06.017

2021

Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy

Tang Y, Xu Q, Hu L, Yan X, Feng X, Yokota A, Wang W, Zhan D, Krishnamurthy D, Ochayon DE, Wen L, Huo L, Zeng H, Luo Y, Huang LF, Wunderlich M, Zhang J, Vivier E, Zhou J, Waggoner SN, Huang G

Cancer discovery · 2021 Dec 1 · PMID 34193438

View on PubMed DOI: 10.1158/2159-8290.CD-20-0833

2021

Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms

Luo H, Liu D, Liu W, Wang G, Chen L, Cao Y, Wei J, Xiao M, Liu X, Huang G, Wang W, Zhou J, Wang QF

European journal of human genetics : EJHG · 2021 Aug · PMID 33867526

View on PubMed DOI: 10.1038/s41431-021-00886-x

2021

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu X, Chen Z, Shen W, Huang G, Sedivy JM, Wang H, Ju Z

Signal transduction and targeted therapy · 2021 Jun 28 · PMID 34176928

View on PubMed DOI: 10.1038/s41392-021-00646-9

2021

STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms

Qu S, Jia Y, Wang H, Ai X, Xu Z, Qin T, Pan L, Li B, Huang G, Gale RP, Xiao Z

Leukemia & lymphoma · 2021 Jun · PMID 33410350

View on PubMed DOI: 10.1080/10428194.2020.1869964

2021

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J

Nature communications · 2021 May 14 · PMID 33990599

View on PubMed DOI: 10.1038/s41467-021-23152-6

2021

Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration

Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z, Chen C, Ju Z

Cell reports · 2021 Mar 30 · PMID 33789111

View on PubMed DOI: 10.1016/j.celrep.2021.108922

2021

VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder

Huang H, Zhang W, Cai W, Liu J, Wang H, Qin T, Xu Z, Li B, Qu S, Pan L, Huang G, Gale RP, Xiao Z

Experimental hematology & oncology · 2021 Mar 19 · PMID 33741056

View on PubMed DOI: 10.1186/s40164-021-00217-2

2021

Molecular and clinical features of myeloid neoplasms with somatic DDX41 mutations

Qu S, Li B, Qin T, Xu Z, Pan L, Hu N, Huang G, Peter Gale R, Xiao Z

British journal of haematology · 2021 Mar · PMID 32307695

View on PubMed DOI: 10.1111/bjh.16668

2021

Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model

Zhao J, Sui P, Wu B, Chen A, Lu Y, Hou F, Cheng X, Cui S, Song J, Huang G, Xing C, Wang QF

Leukemia · 2021 Feb · PMID 32503976

View on PubMed DOI: 10.1038/s41375-020-0894-x

2021

Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition

Fan C, Zhao C, Zhang F, Kesarwani M, Tu Z, Cai X, Davis AK, Xu L, Hochstetler CL, Chen X, Guo F, Huang G, Azam M, Tian W, Lu QR, Zheng Y

Proceedings of the National Academy of Sciences of the United States of America · 2021 Jan 5 · PMID 33443202

View on PubMed DOI: 10.1073/pnas.2020102118

2021

Arsenic Dispensing Powder Promotes Erythropoiesis in Myelodysplastic Syndromes via Downregulation of HIF1A and Upregulation of GATA Factors

Fan T, Feng X, Yokota A, Liu W, Tang Y, Yan X, Xiao H, Wang Y, Deng Z, Zhao P, Wang M, Wang H, Ma R, Hu X, Huang G

The American journal of Chinese medicine · 2021 · PMID 33641653

View on PubMed DOI: 10.1142/S0192415X2150021X

2021

Dynamics of Blood Viral Load Is Strongly Associated with Clinical Outcomes in Coronavirus Disease 2019 (COVID-19) Patients: A Prospective Cohort Study

Chen L, Wang G, Long X, Hou H, Wei J, Cao Y, Tan J, Liu W, Huang L, Meng F, Huang L, Wang N, Zhao J, Huang G, Sun Z, Wang W, Zhou J

The Journal of molecular diagnostics : JMD · 2021 Jan · PMID 33122141

View on PubMed DOI: 10.1016/j.jmoldx.2020.10.007

2020

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Chen L, Long X, Xu Q, Tan J, Wang G, Cao Y, Wei J, Luo H, Zhu H, Huang L, Meng F, Huang L, Wang N, Zhou X, Zhao L, Chen X, Mao Z, Chen C, Li Z, Sun Z, Zhao J, Wang D, Huang G, Wang W, Zhou J

Cellular & molecular immunology · 2020 Sep · PMID 32620787

View on PubMed DOI: 10.1038/s41423-020-0492-x

2020

Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre

Huang H, Xu C, Gao J, Li B, Qin T, Xu Z, Ren S, Zhang Y, Jiao M, Qu S, Pan L, Hu N, Liu J, Cai W, Zhang Y, Wu D, Zhang P, Gale RP, Huang G, Zhou J, Shi L, Xiao Z

Blood cancer journal · 2020 Aug 14 · PMID 32801296

View on PubMed DOI: 10.1038/s41408-020-00349-4

2020

Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial

Cao Y, Wei J, Zou L, Jiang T, Wang G, Chen L, Huang L, Meng F, Huang L, Wang N, Zhou X, Luo H, Mao Z, Chen X, Xie J, Liu J, Cheng H, Zhao J, Huang G, Wang W, Zhou J

The Journal of allergy and clinical immunology · 2020 Jul · PMID 32470486

View on PubMed DOI: 10.1016/j.jaci.2020.05.019

2020

Mutational features of myelodysplastic syndromes with Auer rods reveal them are more akin to acute myeloid leukemia

Huang H, Qin T, Xu Z, Shi Z, Li B, Pan L, Hu N, Qu S, Huang G, Gale RP, Xiao Z

British journal of haematology · 2020 Mar · PMID 31880320

View on PubMed DOI: 10.1111/bjh.16326

2020

DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells

Bera R, Chiu MC, Huang YJ, Huang G, Lee YS, Shih LY

Oncogenesis · 2020 Feb 3 · PMID 32015320

View on PubMed DOI: 10.1038/s41389-020-0191-6